Department of Pharmacology and Toxicology

Diploma theses

Institute of Pharmacology

General veterinary medicine:

• Occurence of Malassezia yeasts in dogs and their owners
• Synergistic effect of azole antifungals and selected essential oils to Malassezia pachydermatis yeasts
• Efficacy of antimycotics on biofilm forming isolates of Malassezia pachydermatis
• Synergistic effect of plant essential oils and chosen antimycotics against antimycotic-resistant Malassezia pachydermatis isolates
• Comparison of the sensitivity of M. pachydermatis isolates from healthy and diseased dogs to antifungal agents
• Effectiveness of selected antiseptic agents against Candida albicans
• Malassezia pachydermatis and biofilm formation

Pharmacy:

• Antifungal efficacy of essential oils in combination with conventional antifungal agents against Candida albicans yeast isolates
• Susceptibility testing of biofilm forming Candida albicans isolates to conventional antimycotics
• Analysis of prescription of drugs affecting the digestive tract in humans
• Vitamin and mineral supplements in supermarkets and grocery stores
• Monitoring of biofilm formation in yeasts of the genus Candida
• Monitoring the success of pharmacological treatment of endometrial lesions in ovaries
• The most commonly prescribed antibiotic eye drops
• Phytotherapeutics useful in digestive tract diseases
• Phytotherapeutics useful in urinary tract diseases
• Determination of total phenols in plant extracts of Lamiaceae family
• Effect of humic substances on antioxidant activity of plant extracts
• Effect of dandelion (Taraxacum officinale) on metabolic acitivity of cells
• The use of cytotoxic testing in the pharmaceutical industry
• Effect of extractant on pharmacological properties of dandelion leafs extracts
• Effect of extractant on pharmacological properties of dandelion flower extracts
• Evaluation of heavy metals nephrotoxicity using model cell line

Post BSc. General veterinary medicine:

• The antifungal efficacy of plant essential oils on Malassezia pachydermatis yeast isolates
• Antimycotic effect of propolis extract against Malassezia pachydermatis isolates
• Efficacy of combination of plants essential oils and conventional antimycotics on antimycotic-resistant Malassezia pachydermatis isolates
• Antifungal activity of selected antiseptic compounds against Malassezia yeasts
• Effect of extraction solvent on pharmacological properties of Taraxacum officinale
• Pharmacologic effect of Agrimonia eupatoria extracts
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Doctoral thesis:

• The toxicity of plant extracts in combination with antimicrobial substancies
• Cytotoxic effects of selected plant extracts
• Clinical importance of drug interactions in patients with hypertension
• Biological activity of agrimony extract
• The perspective uses of antibiotics in gastroenterology - the clinical application of rifaximin
• Nephroprotective activity of selected plant extracts
• Indomethacin as a choice in the prevention of intracranial haemorrhage in newborns
• Evaluation of lipid-lowering agents used in clinical practice
• Synergistic effect of essential oils against Candida yeasts
• Effectiveness of anti-anaemic treatment during pregnancy
• Pharmacotherapy of selected community-acquired pneumonia
• Analysis of the pharmacotherapy of peptic gastroduodenal ulcer disease
• Possibilities of pharmacotherapy of atopic dermatitis
• Sleep disorders and possibilities of their pharmacotherapy
• Efficacy of essential oils on selected parameters in the model organism
• Biosynthesis of nanoparticles and their antimycotic effect
• Pharmacotherapy of Pityriasis versicolor
• Synergistic effect of plant oils and conventional antimycotics in the treatment of candidiasis
• Contemporary Possibilities of Pharmacotherapy of Epilepsy

Postgraduate thesis:

• In vitro study of the antifungal activity of selected antimycotics and natural drugs
• Toxinogenicity and toxicity of F. graminearum and the possibilities of their elimination

Institute of Toxicology

Diploma theses 2017/18:

• Determination of acute toxicity of selected carbamates to honey bee larvae (Apis mellifera)
• Determination of toxicity of the active substances and adjuvants of pharmaceutical preparations
• Determination of LC50 of selected drugs with psychotic effect
• Toxicity of voriconazole on aquatic organisms
• Toxicity of fluconazole on aquatic organisms
• The use of cytotoxic testing in the pharmaceutical industry
• Inhibitory effect of plant extracts on Penibacillus larvae
• Acute toxicity of fluconazole on selected aquatic species
• Acute toxicity of fluconazole on selected aquatic species
• Acute toxicity of voriconazole on selected aquatic species

Doctoral thesis:

• Determination of toxicity of the active substances and adjuvants of pharmaceutical preparations
• Exposure to arsenic, cadmium, mercury and nicotine in water on humans and animals
• Evaluation of toxic effect of metronidazole, fluconazole and voriconazole on selected cell cultures in vitro

Postgraduate thesis:

• The toxic effects of the bracket to the different types of biological models
• The impact of selected pesticides and other chemicals on the vitality of honeybee colonies

Institute of Human and Clinical Pharmacology

Pharmacy – diploma theses 2017/18:

• Therapy Parkinson´s disease
• Effect of exogenously administered testosterone on its endogenous function and level
• Multifactorial treatment of a diabetic patient. Evaluation of co-morbidities and possible drug interactions
• Pharmacotherapy of angina pectoris
• Hypertension in the pregnancy and its therapy
• Analysis of herbal medicines recommended in the treatment of selected immune related disorders
• Silymarin and its therapeutic use in liver damage
• The causes and the most effective ways to treat amenorrhea in fertile women
• Causes of skin disease vitiligo and current treatment options
• The most common oncological diseases in childhood and the consequences of their treatment in young patients
• Pharmacotherapy of patients with chronic ischemic heart
• Current trends of pharmacological therapy of Parkinson disease
• Possibilities of therapy of dysmenorrhea and its influence on the organism
• Pharmacotherapeutical management of patients with heart failure

A full list of all published diploma and rigorous theses can be found at the Institute of Scientific Information and Library of UVLF as well as at the Institute of Human and Clinical Pharmacology of UVLF.