The Institute of Anatomy deals in complex in vivo pre-clinical testing of new types of biomaterials developed in cooperation with the collective of the Institute of Materials Research SAV. Preliminary results at the in vitro and ex ovo levels confirmed the safety and biocompatibility of the biomaterials developer. Currently underway are pre-clinical preliminary studies on the in vivo models of large animals, which confirm the effectiveness and efficiency of treating extensive defects of cartilaginous tissue, applying porous biopolymer composite systems. The aim of the cooperation is to markedly accelerate the healing of defects in the cartilaginous tissue with complete healing and the creation of a comparable tissue and subchondral bones as compared to the surrounding, original tissue. The results contribute to the newest knowledge about regeneration of cartilaginous and bone tissue, and the subsequent application of developed functional biomaterials in the clinical practice of veterinary and human medicine. The focus of the department is oriented toward study of the vascular system of laboratory animals. Regarding the high morphological variability of the vascular system with varied prevalence in individual parts of the body and with the eventual occurrance of anastomosis and alternative routes, we monitor the arrangement of the vascular system with emphasis on anatomical variation, the network of veins, changes in existence and positions of the vessels, formation of shared branches and analysis of the mutual vascular relationships. We compare the anatomical continuity of the vascular system of laboratory animals and people, because progress in the human clinical practice is accompanied by similar procedures in the experimental area and laboratory animals are an important model for new-age clinical study. Our results indicate possible alternative routes of the vascular system of organs (brain, heart, liver), which play key roles in experiments requiring ligation of the vessels or adding thrombogenic materials in those studies which induce ischemia of the organs, venous infarctions or indicate obstruction, and whose success is limited to anastomotic organization and intercommunication of the vascular system.
The scientific research activity of the workplace of Histology and Embryology is for a long time focused on the study of the structure and ultrastructure of selected tissues and organs of animals that have been exposed to various physical or chemical environmental risk factors. In the recent period, scientific research activity focuses on clarifying the influence of non-ionizing electromagnetic radiation applied during prenatal development on selected organs and tissues of adult and juvenile rats as well as organs and tissues of chicken embryos. Research is carried out through conventional histopathological examination methods using light and transmission electron microscopes as well as through modern histochemical and immunohistochemical examination methods. The scientific and research activity of the workplace is currently carried out in cooperation with the Department of Theoretical and Industrial Electrical Engineering, Faculty of Electrical Engineering and Informatics, Technical University in Košice
The secientific work of pathological anatomy workplace is focused on:
The institute also performs diagnostic autopsies (necropsies) and histopathological and cytological diagnostics for veterinary workplaces from all over Slovakia