Department of microbiology and immunology

Diploma theses

Safety of Food and Feed – bachelor thesis:

• Alimentary intoxications and methods for detection of enterotoxins in food
• Virulence factors and their role in the pathogenesis of diseases of gastrointestinal tract caused by enterobacteria

General veterinary medicine - diploma thesis:

• Bacterial infections of urinary tract in dogs and cats
• Diagnostics of atopy in dogs
• Effect of exopolysaccharides isolated from L. reuteri on the ability of salmonella to adhere and invade IPEC-1 cells
• Effect of humic acid application on the cellular immune response of poultry
• Effect of probiotic bacteria on the activity of phagocytes in dogs
• Effect of the Lactobacillus reuteri probiotic strain on the cellular immune response of mice infected with enterotoxigenic E. coli
• Feline urinary tract infections and their treatment
• Incidence of pyoderma in dogs according to the breed and age of the animal
• Molecular-biology diagnostics methods for detection and characterization of Campylobacter spp.
• Differences in composition of oral microbiota in cats of various age
• Occurrence of resistant strains in bacteria isolated from the oral cavity of dogs
• Oral microbiota and stomatitis occurence in reptiles
• PCR detection of selected viral pathogens in wild boar (Sus scrofa) from Slovakia
• Prevalence of Staphylococcus aureus as important causal agent of mastitis in milk of dairy cows
• Replication of Tribeč virus in cell cultures of human and animal origin
• Selection of probiotic bacteria for bees
• Study of the biofilm formation process of selected Lactobacilli in the gastrointestinal tract of conventional mice
• The influence of supplementation of polyunsaturated fatty acids (PUFA) and probiotic lactobacilli on metabolic parameters and intestinal metabolism in gnotobiotic piglets after infection by E.coli K 88
• The study of bioactive substances in selected dental biofilm bacteria
• The study of Gram positive cariogenic bacteria isolated from dental biofilm
• The use of gnotobiotic laboratory animals in the study of inflammatory bowel diseases
• Therapeutic potential of transplantation of faecal microbiota (FMT)
• Tick-borne arboviruses in free living rodents
• Tribeč virus (genus Orbivirus, Great Island virus serogroup) in birds and livestock animals in Slovakia
• Usutu virus (genus Flavivirus) in the avifuana of wetland ecosystem of Drienov
• Influence of probiotic lactobacilli and pathogenic bacteria on the isolated intestinal cells of rainbow trouts (2021) 
• Use of probiotics in honeybee breeding (2021) 
• Isolation and identification of bacteria causing mastitis in ruminats (2021)
• Isolation and identification of bacteria in the milk of dairy cows (2021)
• Isolation and identification of bacterial strains causing otitis in dogs and cats (2022)
• Isolation and identifikation of bacterial strains causing pyometra in small animals (2022)
• Isolation and identification of bacterial strains causing diseases in reptiles (2022)
• Gut microbiota in the pathogenesis of inflammatory bowel diseases (2023) 
• Neglected zoonotic orbivirus (Kemerovo virus and Tribeč virus) infections in autochthonous horses in Nort-Eastern Hungary (2023) 
• Study of the possibilities of using humic substances in honey bees (2024) 
• In vitro study of the innate antiviral immunity (2024) 
• Gut microbiota in the pathogenesis of inflammatory bowel disease (2023)
• The effect of pesticides on the immunity of honey bees (2023) 
• Study of the influence of FMT from a patient with acute ulcerative colitis on pathogenesis of UC using a pseudo germ.free animal model (2024) 
• Comparison of recirculating aquaculture system and flow-through system in smoltification of Atlantic salmon in Norway (2024)
• Occurrence and causes of contagious and environmental mastitis in dairy cows (2024)
• Isolation and identification of bacterial agents of gastrointestinal disease in dogs and cats (2024)
• Study of the possibilities of using humic substances in honey bees (2024) 
• Study of the relationship between the occurrence of the parasite Lepeophtheirus salmonis and the defense capability of Atlantic salmon in norwegian agriculture (2024) 
• Study of the influence of FMT from a patient with acute ulcerative colitis on pathogenesis of UC using a pseudo germ.free animal model (2024) 

Pharmacy:

• Antibiofilm potential of biosurfactants isolated from marine bacteria
• In vitro study of the effect of natural substances on the biofilm production by pathogens
• In vitro study of the properties of beneficial bacteria intended for harmonization of the natural microbiocenosis of the skin
• Influence of application of bioproducts on the cellular immune response of poultry
• Selected in vitro methods for determination of antibacterial activity of essential oils
• The influence of probiotic bacteria stabilised on alginite and its humic extracts on intestinal and overall metabolism of model laboratory animals
• Transplantation of faecal microbiota - alternative method of therapy of ulcerous colitis
• Use of germ-free animal models in biomedical research
• Antibacterial and antibiofilm activity of plant polyphenols against staphylococci isolated from dairy cow milk (2023)

Rigorous thesis:

• Nutritional supplements containing plant extracts and their antimicrobial effects
• Effect of fecal transplant from a patient with chronic inflammatory bowel disease on cellular immune response studied in a mouse model
• Transplantation of faecal microbiota – alternative method of therapy of ulcerous colitis.(2023)

Doctoral thesis:

• Antimicrobial and antibiofilm potential of bioactive products of beneficial microorganisms against multi-drug-resistant pathogens
• Assessment of adverse effects in modulating the immune response in patients with Crohn's disease
• Gastrointestinal infections of bacterial origin, the possibilities of their therapy and protective effects of probiotics
• Immunological aspects of rheumatoid arthritis
• Microbiological analysis of oral microflora from the perspective of dentistry in the veterinary and human medicine
• Postantibiotic colitis in hospital environment
• Study of the effect of the combination of 5-fluorouracil and Immodine on the immune response of mice with colorectal carcinoma
• Surviving of production probiotic strains in selected application form

PhD thesis:

• Analysis of ligand-receptor interactions between Borrelia and the cells of neurovascular unit as basis for development of antiborrelia therapeutics
• Characteristics of immunopharmacological effect of chemicals with potentiated effect on probiotics
• Characterization of biological properties of arboviruses with occurence in Slovakia
• Development and production of peptides against neurovascular pathogens
• Development of protein arrays for identification of the various infections
• Development of single domain antibody fragments (nanobodies) against neuroinvasive Neisseria
• Health aspects of the use of probiotics in veterinary medicine
• Immunomodulators of natural origin in fish and bee farms
• In vitro study of immunomodulatory effect of exopolysaccharides Lactobacillus reuteri
• Species diversity and characterisation of arboviruses and their vectors
• Study of protein interactions between cells of neurovascular unit and neuroinvasive pathogens and its role in the neuropathogenesis
• Study of the effect of substances of natural origin with immunomodulatory effect on the model organism
• Syndrome of neuroinvasive zoonoses in relationship to antigenic diversity and differential diagnostic
• The use of germ-free (gnotobiotic) laboratory animals in research of digestion tract physiology and mutual interactions between natural microflora and digestion tract pathogens
• The use of gnotobiotic animals in research of targeted modulation of intestinal ecosystem in prevention and treatment of inflammatory bowel diseases (IBD)
• Bacterial microbiota of concentration sites of alpine tourism with a focus on the occurrence and pathogenicity of Yersinia enterocolitica in the alpine avifauna
• Use of substances of natural origin with antibacterial effects against fish pathogens
• Study of the effect of substances of natural origin with immunomodulatory effect on a model organism 
• Modulation of intestinal microbiocenosis and immune response of honey bees using probiotic lactobacilli in a new application form 
• Immunomodulators based on probiotic bacteria and their effect on the immune response of salmonid fish 
• Development of a probiotic preparation based on autochronous lactic acid bacteria for salmonid fish 
• Study of the effect of faecal microbiota transplant on selective markers of idiopathic bowel inflammations (IBD) (2024)