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Organisation structure

Department of Chemistry, Biochemistry and Biophysics

Scientific research activity

Research activities of the department are dependent on the research aims of individual institutes and is focused on biochemical research with application in veterinary medicine, toxicology and pharmacy by study of biochemically active substances, their isolation and analysis.

Institute of Pharmaceutical Chemistry

The scientific research activity of the Institute of Pharmaceutical Chemistry is focused on several areas:

  • Study of the antioxidative and antimicrobial activity of extracts from different types of mushrooms (genus Cordyceps, woodgrains, edible mushrooms). Research is also focused on biologically active substances (polysaccharides - glucans, sterols, nucleosides, nitrogen-containing bases) produced by fungi.
  • Determination of the content of additives (preservatives, artificial sweeteners and dyes) in pharmaceutical products to monitor compliance with applicable (valid) legislation in the field.
  • Determination of antioxidant activity of the plant extracts and green synthesis of silver nanoparticles.
  • Study of properties of nanoporous silica-based systems as drug carriers.

Solving the problems in defined areas the Institute cooperates with other departments within the UVLF as well as with other universities. In particular, chromatographic methods (LC, GC, HPLC) and other advanced methods such as NMR, IR spectrometry and X-ray methods are used to obtain experimental results.

Projects:
  • APVV-15-0520: Inteligent nanoporous systems as carriers of drugs
  • APVV-0605-12: Potentiation of vaccines against rabies and other lyssavirus infections using new type of adjuvans and investigation of selected bat pathogens in bat population.
  • VEGA 1/0591/15: Study of selected pathogens in populations of insectivorous bats.
  • KEGA 008UVLF-4/2017: The modernization and the making the teaching process of analytical disciplines in the study programme of pharmcy more attractive.
  • IGA 13/2016: Antioxidant and antibacterial activity of silver nanoparticles prepared using plant extracts.
  • IGA 03/2017: Effect of changes in the growth conditions on a content of biologically active substances with antioxidant activity in fungi of the genus Cordyceps (Fr.) Link.

Institute of Medical Chemistry

The research activity is primarily focused on the oxidative stress as result of xenobiotics (heavy metals, pesticides, pharmaceuticals) action. Changes in food properties as Maillard reactions consequence represent another area of our research.

Projects:
  • APVV-0605-12: Potentiation of vaccines against rabies and other lyssavirus infections using new type of adjuvans and investigation of selected bat pathogens in bat population.
  • VEGA 1/0591/15: Study of selected pathogens in populations of insectivorous bats.
  • VEGA 1/0176/16: Genotoxic and cytogenetic effects of neonicotid insecticides.
  • VEGA 1/0476/16: Study of the application of additives with a high content of polyunsaturated fatty acids potentiating the effect of probiotics to modulate the metabolic and reproductive processes of animals.
  • KEGA 008UVLF-4/2017: The modernization and the making the teaching process of analytical disciplines in the study programme of pharmacy more attractive.

Institute of Biochemistry

Research activities of workers can be divided into four fields:

  • Proteolytic enzymes, some oxidoreductases and peptide growth factors at the level of the basic research as well as in diagnostic practice.
  • Isolation of peptidases from maggots of housefly and common green bottle fly used in larval therapy.
  • Urine metabolomics for cancer detection by using of HPLC technique.
  • Preparation of coordination compounds of Co(II) with 8-hydroxychinolin and study of their antiproliferative effects.
Projects:
  • VEGA 1/0600/14: Digestive proteinases and membrane-bound exopeptidases in larvae of housefly (Musca domestica) and the common green bottle fly (Lucilia sericata) used in larvotherapy.
  • VEGA 1/0258/15: Deciphering the potential factors of neuroinvasive borrelia causing neuroinflammation in CNS.
  • APVV-14-0218: Deciphering the ligand-receptor interactions involved in central nervous system invasion by pathogens and development of targeted therapeutic strategy against neuroinfections

Institute of Biophysics

Members of the institute realize their research in two specializations:

  • Study of the interactions of antiviral and anticancer agents and their derivatives with important biological molecules and membranes with emphasis on the explanation of their mechanism of action. The research is realized on molecular level and has been a part of the project, which is solved on Department of Biophysics PF UPJŠ.
  • Study of the interaction of some pesticides with biomacromolecules with cooperation of Institute of Genetics at UVMP.
Projects:
  • VEGA 1/0176/16: Genotoxic and cytotoxic effects of neonicotinoid insecticides.
  • VEGA 1/0929/16: Noninvasive microRaman and SERS analysis of colours used in culture-historic artefacts on the paper base.