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Organisation structure

Department of Anatomy, Histology and Physiology

Scientific research activity

The scientific research activity of the facility depends on the focus of research of the individual institutes of the department.

Institute of Anatomy

The Institute of anatomy UVLF in Košice deals in complex in vivo pre-clinical testing of new types of biomaterials developed in cooperation with the collective of the Institute of Materials Research SAV. Preliminary results at the in vitro and ex ovo levels confirmed the safety and biocompatibility of the biomaterials developer. Currently underway are pre-clinical preliminary studies on the in vivo models of large animals, which confirm the effectiveness and efficiency of treating extensive defects of cartilaginous tissue, applying porous biopolymer composite systems. The aim of the cooperation is to markedly accelerate the healing of defects in the cartilaginous tissue with complete healing and the creation of a comparable tissue and subchondral bones as compared to the surrounding, original tissue. The results contribute to the newest knowledge about regeneration of cartilaginous and bone tissue, and the subsequent application of developed functional biomaterials in the clinical practice of veterinary and human medicine. The Institute of anatomy in cooperation with the Clinic for small animals Neuroimmunological institute SAV in Bratislava deals with the very current problem of regeneration of the central nervous system (CNS). In recent years for the study of various neurodegenerative diseases the animal model has been required, as well as the domestic animals, mainly dogs and cats. Various neurological diseases (trauma CNS, neurodegeneration caused by ageing and others) are the subject of possible cell therapy. Our shared goal is to test the suitability of cell therapy and its products in in vitro conditions and subsequently with selected clinical patients. Tracking neurodegenerative diseases is also related to monitoring communication of the subarachnoidal space with extracranial components of the lymphatic system. Currently, the collective at the anatomy department is focused on determining the function of the dura mater in lymphatic drainage of cerebrospinal fluid, by means of newly-discovered vascular structures. The aim of this part of the study is to contribute to the understanding of the morphological connection between the CNS and the lymphatic system, in physiological conditions as well as in the case of serious neurogegenerative changes. The focus of the institute is oriented toward study of the vascular system of laboratory animals. Regarding the high morphological variability of the vascular system with varied prevalence in individual parts of the body and with the eventual occurrance of anastomosis and alternative routes, we monitor the arrangement of the vascular system with emphasis on anatomical variation, the network of veins, changes in existence and positions of the vessels, formation of shared branches and analysis of the mutual vascular relationships. We compare the anatomical continuity of the vascular system of laboratory animals and people, because progress in the human clinical practice is accompanied by similar procedures in the experimental area and laboratory animals are an important model for new-age clinical study. Our results indicate possible alternative routes of the vascular system of organs (brain, heart, liver), which play key roles in experiments requiring ligation of the vessels or adding thrombogenic materials in those studies which induce ischemia of the organs, venous infarctions or indicate obstruction, and whose success is limited to anastomotic organization and intercommunication of the vascular system.

Patents:
  • Patent submission: PP 00089-2014 Medvecky L., Giretova M., Petrovova E., 2014: Biopolymer composite system for cartilage regeneration.
  • Patent: 288348-2016 Medvecky L., 2016: Calcium-phosphate cement powder mixture and process its preparation.
Projects:
  • Advanced implants with seeded stem cells for the regeneration and reconstruction of hard tissues, OP Research and development, Code ITMS project no.: 26220220032, research years 2010 - 2012.
  • Center of excellence for biomedical technologies, OP Research and development, Code ITMS project no. 26220120066, research years 2010 - 2015.
  • APVV-15-0613: Study of functional bio-implants and stem cells for CNS regeneration, research years 2016 – 2020.
  • VEGA 1/0046/16: CAM – alternative animal model for study of biomaterials, research years 2016 – 2019.
  • KEGA 008UVLF-4/2016: Implementation of interactive education in practical anatomy of study program Pharmacy, research years 2016 - 2019.
  • VEGA 1/0571/17: The morphological determination of CNS connection with extracranial lymphatic system under normal and pathological conditions, research years 2017 - 2020.
  • KEGA 013UVLF-4/2017: The application of advanced imaging technologies into the educational process of the anatomy to enhance the effectiveness of teaching and support integration with practice, research years 2017 – 2020.

Institute of Histology and Embryology

Scientific-research activities of the Institute of histology and embryology focus on the study of the influence of various xenobiotics on the structure of organs of various animal species. The staff of the Institute currently investigates morphological changes in adult and juvenile rats resulting from the influence of electromagnetic radiation. The observations are based on light and transmission electron microscopy and are supplemented with a number of biochemical methods. The scientific-research activities are carried out in collaboration with the Neurobiological institute of SAS with focus on projects related to the influence of electromagnetic radiation on neurogenesis. Within the project KEGA, the staff of the Institute participates in preparation of teaching materials and in upgrading of teaching within the study programme Cynology.

Projects:
  • VEGA 1/0037/12: The effect of electromagnetic radiation on the neurogenesis and the structure of the rat testes, research years 2012 - 2014.
  • VEGA 1/0214/15: The effect of electromagnetic radiation on the structure of some organs of sexually immature rats, research years 2015 – 2017.
  • KEGA 007UVLF-4/2014: New ways of application of e-learning in the study of subject: Basics of morphology - Histology for cynologists, research years 2014 – 2016.

Institute of Physiology

The research activity of the Institute of Physiology focuses on the influence of the application of natural additives on the modulation of metabolic and reproductive processes in animals and on toxicological issues generally and the effect of snake poisons on the organism in particular. The members of the Institute participate in the modernization of the teaching for the subject Cynology as part of the KEGA project.

Projects:
  • VEGA 1/0476/16: Study of the influence of supplementation of additives with high content of polyunsaturated fatty acids capable of potentiating the effect of probiotics on modulation of metabolic and reproductive processes in animals, research years 2016 – 2019.
  • VEGA 1/0392/17: Impact of contaminants - products of petroleum industry on ovarian functions of different animal species. Use of medicinal plants for reducing the effect of these contaminants, research years 2017 – 2020.
  • VEGA MŠ SR 1/0613/13: Study of the effect of herbs rooibos and yukka on the ovarian functions and metabolism in domestic animals, research years 2013 – 2015.
  • VEGA MŠ SR 1/0706/12: Modulation of metabolic processes by probiotic microorganism and polyunsaturated fatty acids (PUFAs) in the pigs, research years 2012 – 2014.
  • VEGA MŠ SR 1/0579/12: A comparison of two geographically different populations of European adder species (Vipera berus) with the aspect of their anatomy, morphometry of the venom apparatus, ecology and their significance as potential hosts of their ectoparasite-borne pathogen, research years 2012 – 2014
  • KEGA 006-4/2015: The modern form of education and innovation of the basic physiology for cynology studies, research years 2015 - 2017.
  • IGA 15/2016: Modulation of reproductive abilities of pigs by flaxseed and health-promoting microorganisms.